LIFE SCIENCES & CHEMISTRY
1.
A perfume chemist working on a new formulation would like to find a co-solvent,
perhaps an alcohol, that ensures solubility of all the ingredients and a clear
solution. Alcohols with a boiling point between 100-200°C, and a melting point
between 50-100°C can be considered.
A Knovel
advanced search of (keyword) ALCOHOL;
(physical constants) BOILING POINT is between 100 – 200;
and (physical constants) MELTING POINT is between 50 – 100, will bring up
the Knovel Critical Tables. A Knovel Interactive Table will show
properties for 25 alcohol compounds that match the boiling point and melting
point criteria.
2.
An office manager has recently been tasked with finding new office space. The
office he has chosen is in a great location and is very reasonably priced.
However, there is asbestos in the building. He needs to find out if .002 fibres
per cubic centimeter is a safe level.
A Knovel
keyword search of ASBESTOS and
CUBIC CENTIMETER will bring up
Patty's Industrial Hygiene. This title will show the office manager
that the acceptable level of asbestos for the workplace, as determined by OSHA
is 0.2 fibers per cubic centimeter of air, well over the building’s level.
3.
An engineering manager at a company that makes valves has an application that
will require a valve to be placed in river water where barnacles have been a
problem. The project has been delayed for over a year while he has searched for
a coating to put on stainless steel that will prevent barnacles from attaching
to the interior of the valve.
A Knovel
keyword search of STEEL and
BARNACLES will bring up
Fungicides, Biocides and Preservatives for Industrial and Agricultural
Applications, which tells him to use BIOMET TBTF (Tributyltin Fluoride)
Anti-Foulant for Marine Paints. Without a Knovel search, the engineer would not
likely have looked in this book, which was published in 1987, or have been able
to find the answer within it.
4.
A food chemist is trying to find a chemical
that will add the scent of pineapple to a new ice cream she is developing. The
chemical needs to have a molecular weight of less than 160 g/mol.
A Knovel
keyword search of PINEAPPLE will
yield the Food Chemicals Codex. The chemist can open a Knovel
Interactive Table containing data on flavor chemicals. By using the “Find Data
in Table” (any part of cell) option, she can identify all substances that
have a PINEAPPLE odor. One substance, Allyl Hexanoate, has a molecular
weight of 156.22 g/mol.
5.
A food manufacturing company plans to produce a
new spice flavor by using an oleoresin (prepared by solvent extraction of ground
spices). The food technologist plans to use acetone as the solvent for
extraction, given its wide availability and economical cost. However, it is
necessary when using chemicals in commercial food preparation to ensure the
correct purity of the substances used. The food technologist would like to know
the purity of acetone needed to meet acceptable standards, and what tests can be
performed to measure its purity.
A Knovel
keyword search of ACETONE,
limited to “Food Science,” will yield the Food Chemicals Codex,
Interactive Table-Monographs. Viewing the acetone monograph, will show
that Assay value is "Not less than 99.5% and not more than 100.5% of C3H6O,
by weight." Also shown, are a variety of tests to verify purity.
6.
A man working in a helicopter manufacturing
plant was having a rough morning – he poured a cleaning solution containing
calcium carbonate into his coffee instead of creamer. His co-workers need to
know right away how to help him.
A Knovel
keyword search of CALCIUM CARBONATE
and FIRST AID will bring up
Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens,
which tells the group that vomiting should be induced and the man should be
taken to the hospital immediately.
7.
A graduate student at one of the leading
medical universities is in the process of completing a research study on
cell-based diseases and is trying to find information to map the disease of a
certain chromosome-chromosome 19.
Using Knovel,
the student performs a keyword search using
chromosome 19
and
disease. The search retrieves information in Wiley Encyclopedia
of Molecular Medicine-Volumes 1-5. The student can now easily find the
many diseases that are localized on this chromosome and easily work with the
information because it is formatted in Knovel’s HTML Reader.
8. A
non-profit group in a small community is working with an engineering group to
create a bioprocessing plant to clean up years of contamination from a now
dormant industrial plant. As part of the planning process, the non-profit group
is drafting an outline to present at a town board meeting. One of the critical
parts of the outline is to estimate all of the necessary equipment that is
needed so that budgets can be set.
Using Knovel,
a representative of the group performs a keyword search using
plant and
equipment,
limiting the search to the “Biochemistry, Biology and Biotechnology” Subject
Area. The search retrieves information in
Encyclopedia of
Bioprocess Technology - Fermentation, Biocatalysis, and Bioseparation, Volumes
1-5.
The individual can now get an outline of the equipment and resources that are
necessary to budget for.
9. A
technician has just started a new job at small pharmaceutical company. The
technician has many years of experience operating chromatography instrumentation
in the environmental testing field, but has little experience with
pharmaceutical methods. The first task that the new technician is assigned to is
the validation of a liquid chromatograph.
Using Knovel,
the technician performs a keyword search using
CHROMATOGRAPHY and
VALIDATION as keywords, limiting the
search to the “Pharmaceuticals, Cosmetics and Toiletries” Subject Area. The
search retrieves information in
Biopharmaceuticals, an
Industrial Perspective,
which provides an outline and details on how to properly perform an instrument
validation. The technician now has a roadmap, created by professionals in the
Pharmaceuticals industry, to follow.
10. A
formulations chemist working at a personal care products company has been tasked
with designing a new hair treatment. Due to all the media publicity about UV
danger, the product needs to provide protection to UV light as well as
compliment the other hair-care products the company offers.
Using Knovel,
the chemist performs a keyword search using
PROTECTION and HAIR as
keywords, limiting the search to the “Pharmaceuticals, Cosmetics and Toiletries”
Subject Area. The search retrieves information from
Cosmetic and Toiletry
Formulations, Volume 6 (2nd Edition),
which provides details on other similar products and their formulations. The
chemist now has the background needed to start the work.
11.
A safety engineering working
with the HAZMAT team from a local community is working on preparedness planning
procedures for a propane storage facility which is about to open for business.
Part of the planning documentation involves estimating the rate of discharge of
the propane gas should a storage tank be punctured. The findings from the study
will need to be documented and placed in a report to the community’s supervisory
commission.
A Knovel
keyword search using GAS DISCHARGE
and HOLE, will yield the
Guidelines for Chemical Process Quantitative Risk Analysis. Viewing the
text, the engineer finds that the data has been made interactive my Knovel. The
engineer simply needs to click inside the blue (live) outline in the text, and
the data and calculations are automatically formatted in an Excel spreadsheet.
He engineer can then easily merge these spreadsheet data calculations into the
planning report for the community commission.
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